| 盐制女贞子化学成分的UPLC-Q/TOF MS鉴定研究 |
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| 引用本文： | 肖雪,许思敏,高映敏,黎珊珊,吴春蓉,严诗楷.盐制女贞子化学成分的UPLC-Q/TOF MS鉴定研究[J].现代食品科技,2019,35(10):253-260. |
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| 作者姓名： | 肖雪 许思敏 高映敏 黎珊珊 吴春蓉 严诗楷 |
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| 作者单位： | 广东药科大学中医药研究院,广东广州510006;广东省代谢病中西医结合研究中心,广东广州510006;广东省代谢病中西医结合研究中心,广东广州510006;上海交通大学药学院,上海200240 |
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| 基金项目： | 广东药科大学“创新强校”项目（2015cxqx164） |
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| 摘 要： | 采用超高效液相色谱-四极杆飞行时间质谱（UPLC-Q/TOF MS）技术对盐制前后不同形状女贞子的化学成分进行分析，并探讨差异性成分之间的变化规律。采用高效液相色谱法条件：Sharpsil-H C18色谱柱（250 mm×4.6 mm，5 μm），流动相为乙腈-0.1%甲酸水溶液梯度洗脱，柱温25 ℃；流速1 mL/min；进样量5 μL。质谱条件：AB Sciex Triple TOF 5600高分辨串联质谱仪，ESI离子源，正离子与负离子模式下扫描。通过正、负离子质谱信息及元素组成分析，在女贞子肾形生品、肾形盐制品、圆形生品、圆形盐制品的潜在离子中，分别推定出19、21、28、24个化合物。通过UPLC-Q/TOF MS技术，为不同形状的女贞子盐制前后的化学成分分析建立了灵敏度高、分离度高和分析速度快的分析方法，也证明了不同形状的女贞子存在差异性成分，经盐制后成分也存在变化，为后续质量控制和药理研究提供研究基础。
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| 关 键 词： | 女贞子 炮制 化学成分 超高效液相色谱-四极杆飞行时间质谱 |
| 收稿时间： | 2019/4/18 0:00:00 |
Study on Chemical Constituents of Ligustri Lucidi Fructus by UPLC-Q/TOF MS |
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| XIAO Xue,XU Si-min,GAO Ying-min,LI Shan-shan,WU Chun-rong and YAN Shi-kai.Study on Chemical Constituents of Ligustri Lucidi Fructus by UPLC-Q/TOF MS[J].Modern Food Science & Technology,2019,35(10):253-260. |
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| Authors: | XIAO Xue XU Si-min GAO Ying-min LI Shan-shan WU Chun-rong and YAN Shi-kai |
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| Affiliation: | (1.Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China)
(2.Guangdong Research Center for Integrated Traditional Chinese and Western Medicine on Metabolic Diseases, Guangzhou 510006, China),(1.Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China)
(2.Guangdong Research Center for Integrated Traditional Chinese and Western Medicine on Metabolic Diseases, Guangzhou 510006, China),(1.Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China)
(2.Guangdong Research Center for Integrated Traditional Chinese and Western Medicine on Metabolic Diseases, Guangzhou 510006, China),(1.Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China)
(2.Guangdong Research Center for Integrated Traditional Chinese and Western Medicine on Metabolic Diseases, Guangzhou 510006, China),(1.Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China)
(2.Guangdong Research Center for Integrated Traditional Chinese and Western Medicine on Metabolic Diseases, Guangzhou 510006, China) and (2.Guangdong Research Center for Integrated Traditional Chinese and Western Medicine on Metabolic Diseases, Guangzhou 510006, China)(3.School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China) |
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| Abstract: | |
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| Keywords: | Ligustri Lucidi fructus the processing with the salt chemical constituents UPLC-Q/TOF MS |
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