香菇、黑木耳提取液改善大鼠营养性贫血的 效果评价

目的 考察香菇、黑木耳提取液改善营养性贫血的效果。方法 将SD大鼠以缺铁饲料造成营养性贫血模型, 把大鼠随机分为低铁模型组、香菇提取液灌胃组、黑木耳提取液灌胃组、乳酸亚铁对照组及正常对照组, 比较分析了各组大鼠的体重、摄食量、血红蛋白(Hb)含量、红细胞游离原卟啉(FEP)含量、红细胞压积的变化。结果 实验4周后, 香菇、黑木耳提取液灌胃组大鼠与低铁模型组比较, 体重、摄食量、血红蛋白含量与红细胞压积均显著升高(P<0.05), FEP含量则显著降低(P<0.01); 与乳酸亚铁组比较, 中、高剂量组大鼠血红蛋白含量、红细胞压积明显提高(P<0.05), FEP含量显著降低(P<0.01), 体重、摄食量略有升高; 各提取液灌胃组各项指标均接近正常组。结论 香菇、黑木耳提取液均可明显改善营养性贫血大鼠症状。

Evaluation on extracts from Lentinula edodes and Auricularia auricula-judae in improving nutritional anemia in rats

Objective To study the effect of extracts from Lentinula edodes (LE) and Auricularia auricula-judae (AA) on improving nutritional anemia. Methods The SD rats were made into nutritional anemia model by feeding iron deficient diet, then the rats were randomly divided into low iron model group, LE extract gavage group, AA extract gavage group, ferrous lactate control group and normal control group, and the body weight, food intake, content of hemoglobin (Hb), red blood cell free protoporphyrin (FEP) content, and changes of hematocrit of each group were analyzed. Results After 4 weeks, when compared with low iron model group, the rats of LE group and AA group had significant increases (P<0.05) in body weight, food intake, hemoglobin content and hematocrit, while having significant decreases (P<0.01) in FEP content. When compared with ferrous lactate group, the rats of middle and high dose group had significant increases (P< 0.05) in hemoglobin content and hematocrit and significant decreases (P<0.01) in FEP content. In addition, the body weight, food intake increased slightly. Besides, the indicators of extract gavage group were close to normal group. Conclusion The LE and AA extracts could significantly improve the symptoms of nutritional anemia rats.