Investigations of interhemispheric processing: Methodological considerations.

This article is a review and critique of a number of methodological issues pertaining to investigations of information exchange and coordination between the cerebral hemispheres. The methods required to address issues of interhemispheric interaction are demonstrated to be distinct from those typically used in studies of lateralization of function. Methodology in this area is examined in reference to three main topics: (a) the requirements for illustrating that an effect is specific to the interaction of the hemispheres, (b) the requirements for demonstrating that interhemispheric processing relies on a particular neural substrates, and (c) the requirements for making inferences about the role of interhemispheric processing in certain neurobehavioral syndromes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)