| 头孢噻肟酸的环境友好合成工艺 |
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| 引用本文： | 洪玲娟,郑叶敏,汤有坚,钟为慧.头孢噻肟酸的环境友好合成工艺[J].浙江化工,2010,41(3):15-17. |
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| 作者姓名： | 洪玲娟 郑叶敏 汤有坚 钟为慧 |
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| 作者单位： | 1. 浙江工业大学,药学院,浙江,杭州,310014
2. 浙江永宁药业股份有限公司,浙江,台州,318020 |
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| 摘 要： | 以7-ACA为原料,在绿色溶剂2-甲基四氢呋喃中与AE活性酯缩合制备头孢噻肟酸,收率为95%,2-甲基四氢呋喃和副产物2-巯基苯并噻唑均可回收利用。与传统工艺(以二氯甲烷等为溶剂)相比,改进后的工艺操作简单,降低了溶媒消耗和环境污染,产品色级浅,适合工业化生产。
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| 关 键 词： | 头孢噻肟酸 2-甲基四氢呋喃 合成 |
Environmental Friendly Synthesis of Cefotaxime Acid |
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| HONG Ling-juan,ZHENG Ye-min,TANG You-jian,ZHONG Wei-hui.Environmental Friendly Synthesis of Cefotaxime Acid[J].Zhejiang Chemical Industry,2010,41(3):15-17. |
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| Authors: | HONG Ling-juan ZHENG Ye-min TANG You-jian ZHONG Wei-hui |
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| Affiliation: | HONG Ling-juan1,ZHENG Ye-min1,TANG You-jian2,ZHONG Wei-hui1 (1.College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China,2. Zhejiang Yongning Pharmacetucial Co. Ltd,Taizhou 318020,China) |
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| Abstract: | By using 2-methyl tetrahydrofuran (2-MeTHF) as solvent instead of dichloromethane, Cefotaxime acid could be efficiently prepared in 95.3% by condensation of 7 -aminocephalosporanic acid (7 -ACA) and MEAM. The side product 2-mercaptobenzothiazole (M) was isolated and 2-MeTHF could be recycled at the same time. The advantage of the improved process is convenient operation, less amount of solvent, lower cost with environmental friendly, so it is suitable for large scale manufacture. |
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| Keywords: | Cefotaxime acid 2-methyltetrahydrofuran synthesis |
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