Quantitation of Famotidine in Pharmaceutical Dosage Forms Using High-Performance Liquid Chromatography |
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Authors: | Jagdish Parasrampuria V. Das Gupta |
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Affiliation: | a Department of Pharmaceutics, University of Houston, Houston, TX |
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Abstract: | A stability-indicating high-performance liquid chromatography method for the quantitation of famotidine in injections, suspensions and tablets has been developed. The method is precise and accurate with a percent relative standard deviation of 1.1-1.3 based on 5 readings. The excipients present in the dosage forms did not interfere with the assay procedure. The recovery from the synthetic mixtures was quantitative. The samples decomposed under drastic conditions showed a total of 3 new peaks in the chromatograms |
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