| Abstract: | A study was made of a new antidiabetic preparation--taurin in various methods of its administration to rats and rabbits with alloxan and ditisone model of diabetes. A short-term restoration of carbohydrate metabolism was seen after intraperitoneal and intravenous injection in a dose of 200 mg/kg. Oral use of aqueous taurin solution in the same dose failed to produce the desirable result. Microcapsulated taurin with acetylcellulose in the capacity of a filler given per os in a dose of 300 mg/kg restored to the normal glycogen content in the liver and leukocytes, blood and urine sugar level, and the insulin-like activity of blood plasma. Taurin (in a concentration of 3 mg/ml) possessed an insulinogenic action in experiments on fragments of the pancreas isolated from diabetia animals. |
