Significance of platelet-activating factor in mesenteric ischemia-reperfusion |
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Authors: | János Filep Pierre Braquet Tibor Mózes |
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Affiliation: | (1) Department of Pathophysiology, Semmelweis University Medical School, 1445 Budapest, Hungary;(2) Department of Traumatology, Semmelweis University Medical School, 1445 Budapest, Hungary;(3) Department of Institut Henri Beaufour, 92350 Le Plessis Robinson, France;(4) Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, J1H 5N4 Sherbrooke, Quebec, Canada |
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Abstract: | Reperfusion of the ischemic mesenterium is frequently followed by acute circulatory collapse. This review focuses on the possible role of platelet-activating factor (PAF) in ischemia-induced damage. It provides evidence that (i) PAF concentrations are elevated in the mesenteric circulation following temporary ischemia; (ii) administration of exogenous PAF into the superior mesenteric vein mimics many events observed during reperfusion; and (iii) pretreatment of the experimental animals with specific PAF receptor antagonists prevent the circulatory collapse. These findings suggest that PAF may play an important role in the development of circulatory collapse caused by mesenteric ischemia-reperfusion. Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo, Japan, May 1989. |
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