Acetylation of core histones causes the unfolding of 30 nm chromatin fiber: analysis by agarose gel electrophoresis |
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Authors: | WA Krajewski VM Panin SV Razin |
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Affiliation: | Laboratory of Biochemistry, Russian Academy of Sciences, Moscow. |
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Abstract: | In the present work it was directly demonstrated that increased acetylation level of histones causes the decompactization of 30 nm chromatin fiber, as revealed by low-percentage agarose gel electrophoresis. In the light of obtained results the possible molecular mechanism of the decompactization of acetylated fiber is discussed. |
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