Anti-tumor activity, in vitro and in vivo, of some triphenylphosphinegold(i) thionucleobases |
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| Authors: | Webster L K Rainone S Horn E Tiekink E R |
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| Affiliation: | Experimental Chemotherapy and Pharmacology Laboratory Peter MacCallum Cancer Institute East Melbourne Victoria 3002 Australia. |
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| Abstract: | The Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both Ph(3)PAu(6-MP)] and Ph(3)PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. Ph(3)PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin. |
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