| 几种天然活性物对黑色素细胞毒性及美白功效的比较 |
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| 引用本文： | 康琰琰,张美英,邢少璟,熊盛,王一飞,朱艳梅. 几种天然活性物对黑色素细胞毒性及美白功效的比较[J]. 日用化学工业, 2005, 35(6): 361-363,379 |
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| 作者姓名： | 康琰琰 张美英 邢少璟 熊盛 王一飞 朱艳梅 |
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| 作者单位： | 暨南大学,生物医药研究开发基地,广东,广州,510632 |
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| 基金项目： | 广东省自然科学基金团队资助项目（粤科基办[2003]11号） |
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| 摘 要： | 为比较几种天然产物的美白效果及细胞毒性大小，采用小鼠B16黑色素细胞为受试细胞，分别研究了熊果苷及两种不同的海藻多糖对黑色素细胞的细胞毒性、酪氨酸酶活性和黑色素合成的影响。结果表明：熊果苻具有明显的细胞毒件，与之相比，海藻多糖对黑色素细胞活力几乎无影响；3种药物对细胞内酪氨酸酶活性及黑色素合成均有浓度依赖性的抑制作用，且熊果苷的抑制作用高于海藻多糖。
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| 关 键 词： | 化妆品添加剂 海藻多糖 熊果苷 黑色素细胞 细胞毒性 酪氨酸酶 |
| 文章编号： | 1001-1803（2005）06-0361-03 |
| 收稿时间： | 2005-04-18 |
| 修稿时间： | 2005-04-182005-07-27 |
Toxicity and lightening effects of several natural active products on melanocytes |
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| KANG Yan-yan,ZHANG Mei-ying,XING Shao-jing,XIONG Sheng,WANG Yi-fei,ZHU Yan-mei. Toxicity and lightening effects of several natural active products on melanocytes[J]. China Surfactant Detergent & Cosmetics, 2005, 35(6): 361-363,379 |
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| Authors: | KANG Yan-yan ZHANG Mei-ying XING Shao-jing XIONG Sheng WANG Yi-fei ZHU Yan-mei |
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| Abstract: | To study the toxicity and lightening effect of several natural active products on cultured B16 melanocytes cells of mouse, arbutin and two kinds of algal polysaccharide were added into B16 melanocytes cells and the cell viability, tyrosinase activity and melanin content were measm~ respectively. The results showed that arbutin has significant cytotoxicity, while algal polysaccharide has little effect on the cell viability. All of them showed a concentration corrective reduction on tyrosinase activity and melanin content, while the inhibition effect of arbutin is better than that of algal polysaccharides. |
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| Keywords: | additives of cosmetics algal polysaccharide arbutin melanocytes cytotoxicity tyrosinase |
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