Applications of DNA-Functionalized Proteins |
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| Authors: | Zhaoqiu Gong Yuanyuan Tang Ningning Ma Wenhong Cao Yong Wang Shuang Wang Ye Tian |
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| Affiliation: | 1.College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Artificial Functional Materials, Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; (Z.G.); (Y.T.); (N.M.); (W.C.); (Y.W.);2.Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China;3.Institute of Marine Biomedicine, Shenzhen Polytechnic, Shenzhen 518055, China |
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| Abstract: | As an important component that constitutes all the cells and tissues of the human body, protein is involved in most of the biological processes. Inspired by natural protein systems, considerable efforts covering many discipline fields were made to design artificial protein assemblies and put them into application in recent decades. The rapid development of structural DNA nanotechnology offers significant means for protein assemblies and promotes their application. Owing to the programmability, addressability and accurate recognition ability of DNA, many protein assemblies with unprecedented structures and improved functions have been successfully fabricated, consequently creating many brand-new researching fields. In this review, we briefly introduced the DNA-based protein assemblies, and highlighted the limitations in application process and corresponding strategies in four aspects, including biological catalysis, protein detection, biomedicine treatment and other applications. |
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| Keywords: | DNA– protein hybrid structure DNA nanotechnology cancer diagnosis precise programming |
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