| 超临界抗溶剂法制备聚乳酸微球 |
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| 引用本文： | 张苗苗,詹世平,陈畅. 超临界抗溶剂法制备聚乳酸微球[J]. 中国粉体技术, 2009, 15(6): 42-44. DOI: 10.3969/j.issn.1008-5548.2009.06.011 |
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| 作者姓名： | 张苗苗 詹世平 陈畅 |
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| 作者单位： | 1. 大连大学,环境与化学工程学院,辽宁,大连,116622
2. 大连理工大学,流体与粉体工程研究设计所,辽宁,大连,116012 |
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| 摘 要： | 采用超临界抗溶剂技术,对影响聚乳酸(PLA)微球粒径的溶液浓度和溶剂配比进行了初步研究。在温度38℃、压力10 MPa、溶液流速1.0mL/min、喷嘴直径300μm条件下,研究不同溶液浓度和溶剂配比对聚乳酸微粒粒径和粒径分布的影响。结果表明:当聚乳酸质量浓度为10 mg/mL、混合溶剂二氯甲烷和丙酮的体积比为V(CH_2:Cl_2):V(CH_3COCH_3)=1:2时效果最好,得到的粒堆松软,粒径集中在530～950 nm,粒径分布窄,吹干只需12 min。
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| 关 键 词： | 超临界抗溶剂法 聚乳酸微球 溶剂 |
Preparation of Polylactic Acid Ultrafine Particles by Supercritical Anti-solvent Technology |
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| Zhang Miaomiao,Zhan Shiping,Chen Chang. Preparation of Polylactic Acid Ultrafine Particles by Supercritical Anti-solvent Technology[J]. China Powder Science and Technology, 2009, 15(6): 42-44. DOI: 10.3969/j.issn.1008-5548.2009.06.011 |
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| Authors: | Zhang Miaomiao Zhan Shiping Chen Chang |
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| Abstract: | Under the suitable experimental parameters such as temperature (38°C), pressure (10 MPa), solution flow rate (1.0 mL/min) and nozzle diameter (300 μm), the effects of the solution concentrations of polylactic acid (PLA) and the ratio of solvents on the resulting particles, prepared by the supercritical anti-solvent (SAS) technology, were studied. The results of the experiment indicated when the solution concentrations (10 mg/mL), methylene acetone and acetone dichloride mixed solvent(2:1,volume ratio) were applied, more ultrafine particles were obtained, the size of the most particles was 530～950 nm, the CO_2 flow was maintained only for 12 min in order to wash out the residual solvent. |
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| Keywords: | supercritical anti-solvent technology polylactic acid particles solvents |
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