| 复方烟酸辛伐他汀缓释片的制备及体外释放度研究 |
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| 引用本文： | 冉帆,施务务,马凤余,吕晓燕,徐济恒. 复方烟酸辛伐他汀缓释片的制备及体外释放度研究[J]. 安徽化工, 2011, 37(3): 45-47. DOI: 10.3969/j.issn.1008-553X.2011.03.015 |
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| 作者姓名： | 冉帆 施务务 马凤余 吕晓燕 徐济恒 |
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| 作者单位： | 安徽中医学院药剂教研室,安徽合肥,230038;安徽新华学院,安徽合肥,230041 |
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| 摘 要： | 目的：制备复方烟酸辛伐他汀缓释片并考查其体外释放度。方法：采用亲水凝胶骨架材料（HPMC）制备复方烟酸辛伐他汀缓释片;采用紫外分光光度法,以去离子纯化水900mL为溶剂,篮法测定本品释放度,并与参比制剂进行比较。结果：释放曲线经相似因子（f2）判断,与参比制剂相似。结论：本品处方工艺稳定,重现性好,体外累积释放度符合要求。
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| 关 键 词： | 复方烟酸辛伐他汀 制备 亲水凝胶骨架材料 释放度 缓释片 |
Preparation and Dissolution of Compound Simvastatin and Niacin Extended-release Tablets in Vitro |
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| RAN Fan,SHI Wu-wu,MA Feng-yu,LV Xiao-yan,XU Ji-heng. Preparation and Dissolution of Compound Simvastatin and Niacin Extended-release Tablets in Vitro[J]. Anhui Chemical Industry, 2011, 37(3): 45-47. DOI: 10.3969/j.issn.1008-553X.2011.03.015 |
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| Authors: | RAN Fan SHI Wu-wu MA Feng-yu LV Xiao-yan XU Ji-heng |
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| Affiliation: | RAN Fan1,SHI Wu-wu1,MA Feng-yu2,LV Xiao-yan1,XU Ji-heng1(1.Anhui College of TCM,Hefei 230038,China,2.Anhui Xinhua University,Hefei 230041,China) |
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| Abstract: | Objective:To prepare compound simvastatin and niacin extended-release tablets,and evaluate its dissolution in vitro.Methods: Hydrogel matrix materials(HPMC) was used to prepare the tablets.The dissolution was determined by UV-absorption spectrometry in release medium of 900mL water(basket method).The results were compared with those of the reference preparation.Results:The release curve was similar to that reference preparation judging from similar agent(f2).Conclusion: The formula of this preparation is st... |
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| Keywords: | compound simvastatin and niacin preparation hydrogel matrix materials dissolution extended-release tablet |
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