| 氯苯扎利二钠合成中后处理工艺的改进 |
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| 引用本文： | 彭家志,李家明,李丰. 氯苯扎利二钠合成中后处理工艺的改进[J]. 化学世界, 2010, 51(8) |
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| 作者姓名： | 彭家志 李家明 李丰 |
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| 作者单位： | 安徽中医学院药学院,安徽省现代中药重点实验室,安徽,合肥,230031;合肥医工医药有限公司,安徽,合肥,230088 |
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| 摘 要： | 报道了非甾体解热镇痛消炎药氯苯扎利二钠合成中后处理工艺的改进。以2,4-二氯苯甲酸和邻氨基苯甲酸为原料,经Ullmann反应,精制得氯苯扎利;再与氢氧化钠成盐,得氯苯扎利二钠,两步总收率达73%,简化了操作步骤,降低了生产成本,适合工业化生产。
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| 关 键 词： | 氯苯扎利 氯苯扎利二钠 合成 |
Improved After-treatment in Synthesis of Lobenzarit Disodium |
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| PENG Jia-zhi,LI Jia-ming,LI Feng. Improved After-treatment in Synthesis of Lobenzarit Disodium[J]. Chemical World, 2010, 51(8) |
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| Authors: | PENG Jia-zhi LI Jia-ming LI Feng |
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| Abstract: | An improved after-treatment method in synthesis of lobenzarit disodium was reported.Lobenzarit was prepared from 2,4-dichlorobenzoic acid and 2-aminobenzoic acid as raw material by Ullmann reaction,and was recrystallized to give the key intermediate lobenzarit.Then lobenzarit disodium was obtained by salt formation with 10% NaOH with an overall yield of about 73%.Technical parameters were optimized,so that the process was more suitable for industrialization. |
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| Keywords: | lobenzarit lobenzarit disodium synthesis after-treatment |
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