| 维生素C二步发酵培养基优化 |
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| 引用本文： | 朱欣杰,李锦,孟欣欣.维生素C二步发酵培养基优化[J].河北化工,2011,34(6):19-21. |
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| 作者姓名： | 朱欣杰 李锦 孟欣欣 |
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| 作者单位： | 1. 华北制药集团新药研究开发有限责任公司,河北石家庄,050015
2. 河北维尔康制药有限公司,河北石家庄,050031 |
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| 摘 要： | 采用正交实验法对维生素C二步发酵培养基进行了优化,获得的优化配方为玉米浆1%、尿素0.2%、硫酸镁0.02%、磷酸二氢钾0.4%。并且使用10 L发酵罐对发酵配方进行了验证。
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| 关 键 词： | 发酵培养基 正交设计 维生素C 二步发酵 2-酮基-L-古龙酸 |
Optimization of Vitamin C Two-step Fermentation Medium |
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| ZHU Xin-jie,LI Jin,MENG Xin-xin.Optimization of Vitamin C Two-step Fermentation Medium[J].Hebei Chemical Engineering and Industry,2011,34(6):19-21. |
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| Authors: | ZHU Xin-jie LI Jin MENG Xin-xin |
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| Affiliation: | 1.NCPC New Drug Research and Development Co.,Ltd,Shijiazhuang 050015,China;2.Hebei Welcome Pharmaceutical Co.,Ltd,Shijiazhuang 050031,China) |
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| Abstract: | Vitamin two-step fermentation medium was optimized by orthogonal test.Optimized formula：1% corn steep liquor,0.2% urea,0.02% magnesium sulfate,0.4% potassium dihydrogen phosphate.Formula was verified using a 10 L fermentor. |
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| Keywords: | fermentation medium orthogonal design two-step fermentation Vitamin C 2-keto-L-cologne acid |
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