Butyrylcholinesterase K variant and cerebral amyloid angiopathy |
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Authors: | M Yamada N Sodeyama Y Itoh N Suematsu E Otomo M Matsushita H Mizusawa |
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Affiliation: | Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan. m-yamada.nuro@med.tmd.ac.jp |
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Abstract: | BACKGROUND and PURPOSE: Cholinesterases are found histochemically in the vessels affected with cerebral amyloid angiopathy (CAA). A gene for the K variant of butyrylcholinesterase (BCHE-K) may be associated with late-onset Alzheimer's disease (AD). In search of genetic risk factors for CAA, we investigated the association of BCHE-K with CAA. METHODS: The association between the severity of CAA and BCHE-K was investigated in 155 autopsy cases of the elderly, including 48 patients with AD. RESULTS: There was no significant association of BCHE-K with the severity of CAA in the total, AD, or non-AD cases. Status of the epsilon4 allele of apolipoprotein E gene did not influence the results. CONCLUSIONS: Our results may suggest that BCHE-K is not a definitive risk factor for CAA in the elderly, although further study with larger samples is necessary to confirm this. |
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