NK cells can recognize different forms of class I MHC |
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Authors: | RC Su SK Kung J Gariépy BH Barber RG Miller |
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Affiliation: | Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada. |
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Abstract: | NK recognition and lysis of targets are mediated by activation receptor(s) whose effects may be over-ridden by inhibitory receptors recognizing class I MHC on the target. Incubation of normal lymphoblasts with a peptide that can bind to their class I MHC renders them sensitive to lysis by syngeneic NK cells. By binding to class I MHC, the peptide alters or masks the target structure recognized by an inhibitory NK receptor(s). This target structure is most likely an "empty" dimer of class I heavy chain and beta2m as opposed to a "full" class I trimer formed by binding of specific peptide that is recognized by CTL. |
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