CTX/淀粉接枝PLA共聚物微球的制备及药物释放行为

采用乳化-溶剂挥发法,以头孢噻肟钠(CTX)为模型药物,以自制两亲性聚合物淀粉聚乳酸接枝共聚物(ST-g-PLA)为药物载体,制备了CTX/ST-g-PLA载药微球。考察了乳化剂PVA浓度、油水体积比、ST-g-PLA浓度及搅拌速度对微球粒径、载药量及包裹率的影响,采用IR,DSC和SEM等技术对微球结构进行了表征,研究了微球在4种不同介质中的降解性及体外释药性能。结果表明,当PVA浓度为2%,Vo/Vw=1∶6,共聚物浓度为30%时,制备的微球外型规则,分散性好,载药率为8.2%,包载率为49.2%;微球在不同环境中降解速率不同:肠液>碱液>PBS>酸液;较PLA微球,CTX/ST-g-PLA微球有良好的缓释性。

Preparation and release of CTX microspheres encapsulated in starch graft PLA

Microspheres containing drug were prepared by oil-in-water emulsification-solvent evaporation technique,with the self-made amphiphilic and biodegradable polymer,starch graft poly(lactic acid)(ST-g-PLA) as the carrier,and cefotaxime as the model drug.The effect of PVA,oil/water vacuum ratio(Vo/Vw),polymer concentration in organic solvent,and stirring speed on diameter of microsphere,drug loading and ecapsulation efficiency were discussed.The microspheres were characterized by IR,DSC and SEM.The degradation a...