| 近红外光谱技术在中药栀子渗漉液理化指标快速分析中的应用研究 |
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| 引用本文： | 胡浩武,耿炤,李胜华,王木兰,梅玲华.近红外光谱技术在中药栀子渗漉液理化指标快速分析中的应用研究[J].应用化工,2011,40(4). |
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| 作者姓名： | 胡浩武 耿炤 李胜华 王木兰 梅玲华 |
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| 作者单位： | 江西汇仁药业有限公司,研发事业部,江西,南昌,330052 |
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| 基金项目： | "重大新药创制"科技重大专项 |
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| 摘 要： | 用声光可调滤光器(AOTF)-近红外(NIR)光谱法在线分析栀子渗漉液密度及栀子苷含量。在线收集栀子渗漉液样品,建立栀子渗漉液的含量、比重数据库,同时采集近红外光谱图谱,用偏最小二乘(PLS1)法分别建立NIR光谱与含量、比重数据之间的校正模型,并对在线过程中收集的预测集样品进行含量预测来验证所建模型。结果表明,渗漉液NIR光谱与含量、比重数据之间的校正模型相关系数R2分别为0.956 0和0.978 2,外部样品预测平均相对偏差分别为0.09%,2.84%;该方法精密度RSD分别为0.06%,2.96%;稳定性RSD分别为0.63%,1.89%;预测回收率分别为100.0%,99.9%。近红外光谱技术在栀子渗漉液密度及淫羊藿苷含量分析中具有快速、直接、多成分同时测定,并能实现现场分析。
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| 关 键 词： | 栀子渗漉 栀子苷 AOTF 近红外光谱 在线分析 |
Rapid analysis of Zhizi percolation liquid mixture physical and chemical indicators with NIR spectroscopy |
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| HU Hao-wu,GENG Zhao,LI Sheng-hua,WANG Mu-lan,MEI Ling-hua.Rapid analysis of Zhizi percolation liquid mixture physical and chemical indicators with NIR spectroscopy[J].Applied chemical industry,2011,40(4). |
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| Authors: | HU Hao-wu GENG Zhao LI Sheng-hua WANG Mu-lan MEI Ling-hua |
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| Affiliation: | HU Hao-wu,GENG Zhao,LI Sheng-hua,WANG Mu-lan,MEI Ling-hua(Jiangxi Huiren Pharmaceutical Co.,Ltd.,Nanchang 330052,China) |
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| Abstract: | Specific density and geniposide content of Zhizi(fructus gardeniae) percolation fluid were analyzed with acousto-optic-tunable-filter(AOTF)-near infrared(NIR) spectroscopy technology.Zhizi percolation fluid samples were collected online.Database of specific density and geniposide content of Zhizi percolation was established,including NIR spectroscopy.Calibration model of NIR spectroscopy-specific density,and NIR spectroscopy-geniposide content were established with partial least squares(PLS 1),the calibrati... |
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| Keywords: | Zhizi percolation geniposide AOTF NIR spectroscopy analysis online |
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