PLA-PEG-PLA的微波合成工艺及其在鬼臼毒素载药微球中的应用

采用微波法合成PLA和PLA-PEG-PLA,以PLA和PLA-PEG-PLA的粘均分子量和得率为评价指标,对微波功率和微波反应时间进行了单因素实验。以合成的PLA-PEG-PLA为药物载体,采用乳化-溶剂挥发法制备了(Po-dophyllotoxin,PPT)/PLA-PEG-PLA载药微球,考察了载药微球的药物缓释性能。通过傅立叶变换红外光谱(FT-IR)、扫描电子显微镜(SEM)对微波法合成的PLA和PLA-PEG-PLA以及制备的载药微球的微观结构进行了表征分析。结果表明,最佳微波功率为200W,最佳反应时间为30min时,合成的三元嵌段共聚物PLA-PEG-PLA的粘均分子量为5.2×103。体外释药研究表明,PPT/PLA-PEG-PLA-MS具有明显的药物缓释性。

Microwave-assisted polymerization technology of PLA-PEG-PLA and its application in drug-loaded microspheres of podophyllotoxin

PLA and PLA-PEG-PLA was synthesized by microwave-assisted polymerization.By using viscosity-average molecular weight and yield of PLA and PLA-PEG-PLA as evaluation target,the single-factor experiment was carried out for microwave power and microwave reaction time.Using the synthesized PLA-PEG-PLA as drug carrier,PPT/PLA-PEG-PLA drug-loaded microsphere was prepared by emulsion-solvent evaporation method.The drug release property of the microsphere was observed.The microstructure of PLA,PLA-PEG-PLA and drug-loaded microspheres were characterized and analyzed by FT-IR and SEM.It was shown that the viscosity-average molecular weight of the triblock copolymer PLA-PEG-PLA was 5.2×103 when the optimum microwave power and microwave reaction time for synthesizing PLA-PEG-PLA were 200W and 30min,respectively.The result of release in body showed that PPT/PLA-PEG-PLA-MS had obvious sustained-release property.