| Abstract: | Quinoline dicarboxylic anhydride ( 1 ) reacted with p-aminoacetophenone to give a pyrrolopyridine derivative ( 2 ). The compound produced ( 2 ) reacted with hydrazine hydrate, hydroxyl amine hydrochloride, semicarbazide and thiosemicarbazide to produce pyrrolopyridine derivatives ( 3-6 ). Compound 3 reacted with aromatic aldehyde, PhNCS or PhNCO to produce compounds 7-9 . Compound 4 reacted with PhNCO to give the carbamate ester 10 . When compound 5 was boiled with SOC12, the thiadiazolo compound ( 11 ) was obtained. When compound 6 was allowed to react with α-haloesters and α-haloketones, the thiazolo compounds ( 12-14 ) were produced. All the synthesized compounds were tested against some Gram-positive and some Gram-negative bacteria and they gave satisfactory results. |
