Hydrothermally crystallized Sr-containing bioactive glass film and its cytocompatibility |
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Affiliation: | 1. School of Engineering, Chemical Engineering Discipline, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor DE 47500, Malaysia;2. Department of Civil and Environmental Engineering, University of Ulsan, Daehak-ro 93, Mugeo-dong, Nam-gu, Ulsan 680749, Republic of Korea;3. Sustainable Water Alliance, Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor DE 47500, Malaysia |
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Abstract: | Sr-containing bioactive glass film with the Sr/(Ca+Sr) atomic ratio of 20% was sol-gel coated on titanium substrate, followed by hydrothermal treatment in a mixed phosphate solution (8 mM CaHPO4 and 2 mM SrHPO4) and other media at 120 or 140 °C. X-ray diffraction (XRD) analysis confirms amorphous nature of the gel powder calcined at 610 °C, but small peaks of Ca1.8Sr0.2SiO4 or Ca1.5Sr0.5SiO4 are also present. The absorption bands of Si-O-Si, PO4 and OH groups and a weak absorption band of NO3 groups appear in FT-IR spectrum of the calcined gel powder. Hydroxyapatite (HA) is detected for the hydrothermally treated sample by XRD and Raman analyses. Sr-containing HA nanocrystallites are formed on the film through a dissolution and precipitation mechanism in the hydrothermal treatment. The appearant bonding strength is 21±1 MPa for the both samples. In the test with MC3T3-E1 cells, the two coated samples exhibit larger viability, higher ALP levels and better cell morphology than the polished sample. |
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Keywords: | Bioactive glass Sr Sol-gel Hydrothermal Hydroxyapatite Cytocompatibility |
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