基于介孔硼硅酸盐生物活性玻璃微球的可注射复合骨水泥

以溶胶-凝胶法制备的介孔硼硅酸盐生物活性玻璃微球(MBGS)作为固相, 海藻酸钠(SA)溶液作为液相,开发了一种可注射复合骨水泥。对MBGS中氧化硼/氧化硅的比例对其质构性能及骨水泥的可操作性、抗压强度和生物活性的影响进行表征。实验结果表明, 随着硼含量的增加, MBGS的比表面积从161.71 m²/g增大至214.28 m²/g, 平均孔径以及总孔容也随之增长, 加速了玻璃相中钙离子的释放, 使得玻璃与SA的快速交联, 改善了骨水泥可操作性能和力学性能, 凝固时间由21 min缩短至9 min, 抗压强度由3.4 MPa提升至4.1 MPa, 体外矿化性能也随之提高。综合各方面性能表现, BC-30骨水泥兼具良好的可操作性能、力学性能和体外矿化能力, 是最合适的骨水泥组分。总之, 提高MBGS的质构性能是增强复合骨水泥的可操作性、抗压强度和生物活性的有效方法。

An Injectable Composite Bone Cement Based on Mesoporous Borosilicate Bioactive Glass Spheres

An injectable composite bone cement was fabricated by employing Sol-Gel derived mesoporous borosilicate bioactive glass spheres (MBGS) as solid phase and sodium alginate (SA) solution as liquid phase. The effects of the B₂O₃/SiO₂ ratio in MBGS on its textural properties and workability, compressive strength and bioactivity of bone cement were characterized. It is found that with the increase of boron content, the specific surface area of MBGS increases from 161.71 m²/g to 214.28 m²/g, and the average pore size and total pore volume also increase, which accelerates the Ca²⁺ release and rapidly crosslinks MBGS and SA. Thus, the workability, mechanical property and in vitro mineralization of bone cement are significantly improved, as the setting time is shortened from 21 min to 9 min and the compressive strength is enhanced from 3.4 MPa to 4.1 MPa. Comprehensive performance of all aspects, BC-30 bone cement showing good workability, mechanical properties and in vitro mineralization ability, displays the optimal component. Therefore, improving the textural properties of MBGS is an effective method to enhance the workability, compressive strength and bioactivity of composite bone cement.