Rapid synthesis of citrate-zinc substituted hydroxyapatite using the ultrasonication-microwave method |
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| Affiliation: | 1. Centre for Fine Particles Processing and Nanotechnologies, Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Knez Mihailova 35/4, 11000 Belgrade, Serbia;2. Advanced Materials and Nanobiotechnology Laboratory, Department of Bioengineering, University of Illinois, 851 South Morgan Street, Chicago, IL 60607-7052, USA;3. Advanced Materials Department, Jo?ef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia;4. Laboratory for Electron Microscopy, Faculty of Medicine University of Ni?, Dr. Zoran ?in?i? Boulevard 81, 18 000 Ni?, Serbia;5. Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, 9401 Jeronimo Road, Irvine, CA 92618-1908, USA |
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| Abstract: | Bio-inspired citrate-hydroxyapatite (HAP) nanoparticles doped with zinc ions were prepared from mussel shells via a rapid method of ultrasonication and microwave irradiation. It was found that zinc ions can interact with citrate ions in the crystallization process of HAP. The growth of nanocrystals in citrate solution was slower than that in HCl solution. The addition of zinc ions reduced the residue of citrate in the products and increased the crystallinity of HAP. Furthermore, mineral platelets with the length of 29 ± 7 nm and the thickness of 3–5 nm were obtained for Zn/(Zn+Ca) = 5 mol%, which displayed similar morphology with HAP platelets in bone. Moreover, the obtained HAP nanoparticles are promising for use as bone graft materials in biomedical applications. |
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| Keywords: | Hydroxyapatite Microwave Nanostructures Crystal structure |
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