Polyhydroxyalkanoate‐based drug delivery systems |
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| Authors: | Micha? Michalak Piotr Kurcok Minna Hakkarainen |
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| Affiliation: | 1. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland;2. Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden |
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| Abstract: | Microbial polyhydroxyalkanoates (PHAs) have been a subject of significant research interest in the past few decades. The recent development of novel functionalized PHAs has opened up new possibilities to combine the good biocompatibility of PHA‐based drug delivery systems to, for example, improve drug loading and release properties, targeting or imaging functionalities. This mini‐review presents some recent scientific developments in the preparation of functionalized PHAs, PHA–drug and PHA–protein conjugates, multifunctional PHA nanoparticles and micelles as well as biosynthetic PHA particles for drug delivery. These developments in combination with the generally excellent biocompatibility of PHA materials are expected to further expand the interest in PHA materials for drug delivery and other therapeutic applications. © 2016 Society of Chemical Industry |
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| Keywords: | polyhydroxyalkanoate poly(3‐hydroxybutyrate) drug delivery nanoparticle drug conjugate |
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