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Effects of plasma treatment on biocompatibility of poly[(L‐lactide)‐co‐(ϵ‐caprolactone)] and poly[(L‐lactide)‐co‐glycolide] electrospun nanofibrous membranes |
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| Authors: | Pimwalan Techaikool Donraporn Daranarong Jutamas Kongsuk Dheerawan Boonyawan Nursyuhada Haron William S Harley Kyle A Thomson L John R Foster Winita Punyodom |
| Affiliation: | 1. Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand;2. Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand;3. Bio/Polymer Research Group, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia;4. Save Sight Institute, Faculty of Medicine, University of Sydney, Sydney, Australia |
| Abstract: | Poly[(l ‐lactide)‐co ‐(? ‐caprolactone)] (PLCL) and poly[(l ‐lactide)‐co ‐glycolide] (PLGA) copolymers are widely used in neural guide tissue regeneration. In this research, the surface modification of their hydrophilicity was achieved using plasma treatment. Attachment and proliferation of olfactory ensheathing cells on treated electrospun membranes increased by 26 and 32%, respectively, compared to the untreated PLCL and PLGA counterparts. Cells cultivated on both the PLCL and PLGA membranes showed high viability (>95%) and healthy morphologies with no evidence of cytotoxic effects. Cells grown on treated electrospun fibres displayed significant increases in mitochondrial activity and reductions in membrane leakage when compared to untreated samples. The results suggested that plasma treatment of the surface of the polymers enhanced both cell viability and growth without incurring any cytotoxic effects. © 2017 Society of Chemical Industry |
| Keywords: | poly[(l‐lactide)‐co‐(ϵ ‐caprolactone)] poly[(l‐lactide)‐co‐glycolide] electrospun membranes surface modification plasma treatment biocompatibility |