Immunocytochemical co-localization of substance P and calcitonin gene-related peptide in afferent renal nerve soma of the rat |
| |
Authors: | M Burg DS Zahm MM Knuepfer |
| |
Affiliation: | Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, MO 63104. |
| |
Abstract: | Substance P, calcitonin gene-related peptide and somatostatin immunoreactivities have been demonstrated in putative afferent renal nerve fibers in the rat. Utilizing retrograde-tracing and immunohistochemistry, we labeled afferent renal nerve soma throughout dorsal root ganglia T9 to L1. Most (85%) of afferent renal nerve perikarya were immunoreactive for calcitonin gene-related peptide, 21% had substance P immunoreactivity and none had somatostatin immunoreactivity. All renal afferents immunoreactive for substance P also contained calcitonin gene-related peptide. These results provide evidence that calcitonin gene-related peptide and substance P are present and co-localized in afferent renal nerves, and therefore, mediate transmission of afferent renal input to the spinal cord in the rat. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|