One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment |
| |
| Authors: | Zhongxing Miao Yujie Wang Shengjie Li Min Zhang Meng Xu |
| |
| Affiliation: | 1. Department of Gastroenterology Surgery, Dalian Municipal Central Hospital, Dalian Liaoning, China ; 2. Department of Department of Anorectal Surgery, Dalian Municipal Central Hospital, Dalian Liaoning, China |
| |
| Abstract: | The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6. |
| |
| Keywords: | |
|
|
