Preparation of xanthan gum nanogels and their pH/redox responsiveness in controlled release |
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| Authors: | Liping Zhang Jie Xu Quanwu Wen Caihua Ni |
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| Affiliation: | 1. The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, China;2. School of Chemistry and Materials Science, Ludong University, Yantai, 264025 People's Republic of China |
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| Abstract: | Crosslinked xanthan gum nanogels with pH/Redox responsiveness were prepared through an amidation reaction of xanthan gum with cystamine tetra-hydrazide in aqueous solution by “one pot.” The structures and morphologies of the nanogels were characterized by Fourier transform infrared spectroscopy, proton magnetic resonance, dynamic light scattering, scanning electron microscope, and transmission electron microscope. It was found that the nanogels demonstrated good pH/redox dual-responsiveness due to the presence of disulfide bonds and both of amino and carboxyl groups in the polymers. Doxorubicin was loaded in the nanogels and the drug-controlled release was investigated. The disulfide bonds in the crosslinked structure could be reduced by glutathione solutions,leading to breakdown of the crosslinking structure and drug release. The nanogels were biocompatible and they had promising prospects as anti-cancer drug carriers for targeted release. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47921. |
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| Keywords: | controlled release cystine hydrazide dual sensitivity nanogel xanthan gum |
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