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Glass microparticle- versus microsphere-filled experimental dental adhesives |
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| Authors: | Ensanya A Abou Neel Azadeh Kiani Sabeel P Valappil Nicky M Mordan Song-Yi Baek Kazi M Zakir Hossain Reda M Felfel Ifty Ahmed Kamini Divakarl Wojciech Chrzanowski Jonathan C Knowles |
| Affiliation: | 1. Division of Biomaterials, Restorative Dentistry Department, King Abdulaziz University, Jeddah, Saudi Arabia;2. Biomaterials and Tissue Engineering Division, UCL, Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom;3. Department of Health Services Research and School of Dentistry, University of Liverpool, Research Wing, Daulby Street, Liverpool L69 3GN, United Kingdom;4. Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom;5. Advanced Materials Research Group, Faculty of Engineering, University of Nottingham, United Kingdom
Physics Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt;6. Advanced Materials Research Group, Faculty of Engineering, University of Nottingham, United Kingdom;7. The Australian Institute for Nanoscale Science and Technology, The University of Sydney NSW 2006, Sydney, Australia;8. Biomaterials and Tissue Engineering Division, UCL, Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom The Discoveries Centre for Regenerative and Precision Medicine, UCL Campus, London, United Kingdom Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31114, Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31114, Republic of Korea |
| Abstract: | This study aimed to formulate antibacterial dental adhesives. Phosphate-substituted methacrylate adhesives were modified with 0–20 wt % copper-doped glass microparticles. Two shapes of microparticles were used: regular shaped (microspheres) and irregular shaped (microparticles). The morphology/composition, roughness, monomer conversion (DC%), thermogravimetric analysis, and antibacterial action against S. mutans and P. aeruginosa and ion release were investigated. The results showed that microspheres produced adhesives with a relatively smoother surface than microparticles did. The DC% of adhesives increased with increasing glass filler content. Filled adhesives showed polymer decomposition at ~315 °C and glass melting at 600–1000 °C. The weight loss percent of adhesives decreased with increasing weight percent of fillers. Glass microparticles at 0–20 wt % significantly increased the antibacterial action of adhesives against both bacteria. Glass microspheres at 0–5 wt % significantly increased the antibacterial action of adhesives against both bacteria. Only 20 wt % microparticle-filled adhesive showed an inhibition zone similar to tobramycin (positive control). Microparticle-filled adhesives (with >5 wt % filler) significantly reduced S. mutans more than their microsphere counterparts. Microsphere-filled adhesives (with ≤5 wt % filler) significantly reduced P. aeruginosa more than their microparticle counterparts. Microsphere-filled adhesives showed higher Cu release than their microparticle counterparts. Accordingly, phosphate-substituted methacrylate filled with glass could be used as an antibacterial adhesive. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47832. |
| Keywords: | adhesives biomaterials biomedical applications |