| 乳化挥发法和薄膜-超声法制备阿魏酸固体脂质纳米粒工艺比较 |
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| 引用本文： | 高艺敏,张震,陈佩敏,陈钦,周允莹,汪勇,张宁.乳化挥发法和薄膜-超声法制备阿魏酸固体脂质纳米粒工艺比较[J].食品与发酵工业,2019(6):127-132. |
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| 作者姓名： | 高艺敏 张震 陈佩敏 陈钦 周允莹 汪勇 张宁 |
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| 作者单位： | 暨南大学食品科学与工程系广东高校油脂生物炼制工程技术研究中心;广东省粮油副产物生物炼制工程技术研究中心暨南大学"油料生物炼制与营养"联合实验室 |
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| 基金项目： | 国家自然科学基金项目(3170152531671781;31701525);广东省科技计划项目(2017B090907018;2014 A010107014);清远市科技计划项目(2016D008) |
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| 摘 要： | 阿魏酸在食品医药行业应用广泛,但是容易受温度、p H等环境因素的影响。固体脂质纳米粒(solid lipid nanoparticles,SLNs)能有效地保护生物活性物质不被降解。采用薄膜-超声法和乳化挥发法制备阿魏酸固体脂质纳米粒(ferulic acid loaded SLNs,FA-SLNs),通过单因素实验进行制备工艺的选择,分别得到薄膜-超声法和乳化挥发法制备FA-SLNs的适宜工艺条件。实验结果表明,采用薄膜-超声法制备FA-SLNs,阿魏酸添加量10%(质量分数),卵磷脂添加量90%(质量分数),超声时间5 min,可得平均粒径44. 33 nm,电位-12. 35 m V的FA-SLNs,包封率为62. 97%;采用乳化挥发法制备FA-SLNs,阿魏酸添加量4%(质量分数),卵磷脂的添加量16%(质量分数),单硬脂酸甘油酯的添加量80%(质量分数),聚醚F-68质量浓度10 g/L,可得平均粒径141. 37nm,电位-10. 25 m V的FA-SLNs,包封率为69. 54%。薄膜-超声法制得FA-SLNs的粒径较小,乳化挥发法制得的FA-SLNs包封率较高,2种方式在适宜工艺条件下制备得到的样品在4℃下能够稳定储存21 d,未见明显沉淀。
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| 关 键 词： | 薄膜-超声法 乳化挥发法 阿魏酸固体脂质纳米粒 |
Preparation and comparison of ferulic acid solid lipid nano-particles made by emulsification evaporation and thin film-ultrasonic method |
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| GAO Yimin,ZHANG Zhen,CHEN Peimin,CHEN Qin,ZHOU Yunying,WANG Yong,ZHANG Ning.Preparation and comparison of ferulic acid solid lipid nano-particles made by emulsification evaporation and thin film-ultrasonic method[J].Food and Fermentation Industries,2019(6):127-132. |
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| Authors: | GAO Yimin ZHANG Zhen CHEN Peimin CHEN Qin ZHOU Yunying WANG Yong ZHANG Ning |
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| Affiliation: | (Department of Food Science and Engineering, Jinan University, Guangdong University of PetroleumBiorefinery Engineering Technology Research Center, Guangzhou 510632, China;Guangdong Province Grain and Oil by-product Biorefinery Engineering Technology Research Center,Jinan University-Saskatchewan University Joint Laboratory of Oil Biorefinery and Nutrition, Guangzhou 510632, China) |
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| Abstract: | GAO Yimin;ZHANG Zhen;CHEN Peimin;CHEN Qin;ZHOU Yunying;WANG Yong;ZHANG Ning(Department of Food Science and Engineering, Jinan University, Guangdong University of PetroleumBiorefinery Engineering Technology Research Center, Guangzhou 510632, China;Guangdong Province Grain and Oil by-product Biorefinery Engineering Technology Research Center,Jinan University-Saskatchewan University Joint Laboratory of Oil Biorefinery and Nutrition, Guangzhou 510632, China) |
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| Keywords: | film-ultrasonic method emulsification volatile ferulic acid solid lipid nanoparticles |
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