| 超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法快速筛查及定量分析保健品中29种非法添加物 |
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| 引用本文： | 刘 斌,包 懿,郎 乐,王庆峰,石金娥,华 蕾,石增云,侯 宇,张 鑫.超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法快速筛查及定量分析保健品中29种非法添加物[J].食品安全质量检测技术,2019,10(6):1511-1518. |
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| 作者姓名： | 刘 斌 包 懿 郎 乐 王庆峰 石金娥 华 蕾 石增云 侯 宇 张 鑫 |
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| 作者单位： | 吉林省食品检验所;吉林省莱佛士科技有限公司 |
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| 摘 要： | 目的 建立超高效液相色谱-四极杆/静电场轨道阱质谱法(ultra performance liquid chromatographyquadrupole/electrostatic field orbitrap high resolution mass spectrometry, UPLC-Q-Orbitrap HRMS)快速筛查及定量分析保健品中常见29种非法添加物的方法。方法 样品用甲醇进行超声提取,经去离子水稀释后用UPLC-Q-Orbitrap HRMS进行测定。色谱柱选用HSS T3(1.8μm)柱,质谱采用全扫描/数据依赖二级扫描模式,通过一级质谱和二级质谱信息建立的数据库进行高通量筛查及定量分析。对建立的方法进行方法学考察,幵对市售保健品样品进行筛查测定。结果 各组分在0.1～500 ng/mL浓度范围内具有良好的线性,各化合物的检出限为0.3～20 ng/g,回收率为68.2%～105.3%,相对标准偏差为0.4%～11.3%,能够满足日常检测的要求。结论该方法简单快捷,准确度高,可用于检测保健品中非法添加物的日常监管工作。
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| 关 键 词： | 四极杆/静电场轨道阱高分辨质谱 快速筛查 非法添加物 保健品 |
| 收稿时间： | 2019/2/1 0:00:00 |
| 修稿时间： | 2019/2/25 0:00:00 |
Rapid screening and quantitative analysis of 29 kinds of illegally added compounds in diet health foods by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry |
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| LIU Bin,BAO Yi,LANG Le,WANG Qing-Feng,SHI Jin-E,HUA Lei,SHI Zeng-Yun,HOU Yu and ZHANG Xin.Rapid screening and quantitative analysis of 29 kinds of illegally added compounds in diet health foods by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry[J].Food Safety and Quality Detection Technology,2019,10(6):1511-1518. |
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| Authors: | LIU Bin BAO Yi LANG Le WANG Qing-Feng SHI Jin-E HUA Lei SHI Zeng-Yun HOU Yu and ZHANG Xin |
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| Affiliation: | Jilin Institute for Food Control,Jilin Institute for Food Control,Jilin Institute for Food Control,Jilin Institute for Food Control,Jilin Institute for Food Control,Jilin Institute for Food Control,Jilin Raffles Technology Co., Ltd.,,Jilin Institute for Food Control and Jilin Institute for Food Control |
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| Abstract: | |
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| Keywords: | quadrupole/electrostatic field orbitrap high resolution mass spectrometry rapid screening illegally added compounds diet health foods |
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