| 茶多酚的抗癌作用机制及EGCG纳米载体技术研究进展 |
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| 引用本文： | 张杨波, 饶甜甜, 刘仲华. 茶多酚的抗癌作用机制及EGCG纳米载体技术研究进展[J]. 食品工业科技, 2019, 40(16): 343-348. DOI: 10.13386/j.issn1002-0306.2019.16.057 |
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| 作者姓名： | 张杨波 饶甜甜 刘仲华 |
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| 作者单位： | 1. 湖南农业大学教育部茶学重点实验室, 湖南长沙 410128;2. 国家植物功能成分利用工程技术研究中心, 湖南长沙 410128;3. 湖南省植物功能成分利用协同创新中心, 湖南长沙 410128 |
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| 基金项目： | 国家茶叶产业技术体系岗位科学家(CARS-23);长沙市科技计划重大专项(kq1703003) |
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| 摘 要： | 茶多酚是茶叶中重要的功能成分之一,其中以表没食子儿茶素没食子酸酯(EGCG)的活性最高,多项研究表明以EGCG为代表的茶多酚类物质在癌症的预防及治疗过程中起到安全有效的抑制作用。茶多酚在生理pH下稳定性有限,生物利用度低,制约了其在现代治疗中的应用。研究表明纳米载体技术能够大幅提高茶多酚的稳定性和生物利用率,并使其表现出较强的抗癌活性。本文综述了茶多酚中EGCG的抗癌作用机制及EGCG纳米载体技术研究进展,为茶多酚在癌症预防与治疗中的应用提供参考。
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| 关 键 词： | 茶多酚 EGCG 抗癌作用 纳米载体技术 |
| 收稿时间： | 2018-12-11 |
Research Progress on the Anticancer Mechanism of Tea Polyphenol and EGCG Nanocarrier Technology |
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| ZHANG Yang-bo, RAO Tian-tian, LIU Zhong-hua. Research Progress on the Anticancer Mechanism of Tea Polyphenol and EGCG Nanocarrier Technology[J]. Science and Technology of Food Industry, 2019, 40(16): 343-348. DOI: 10.13386/j.issn1002-0306.2019.16.057 |
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| Authors: | ZHANG Yang-bo RAO Tian-tian LIU Zhong-hua |
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| Affiliation: | 1. Tea Key Lab of the Ministry of National Teaching, Hunan Agricultural University, Changsha 410128, China;2. National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China;3. Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China |
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| Abstract: | Tea polyphenol is one of the important functional components in tea.Among them,epigallocatechin gallate( EGCG)has the highest activity. Many studies have shown that tea polyphenol represented by EGCG played a safe and effective inhibitory role in the prevention and treatment of cancer.Due to the limited stability of tea polyphenol at physiological pH and low bioavailability,it restricts its application in modern treatment. Studies have shown that nanocarrier technology can greatly improve the stability and bioavailability of tea polyphenol,and make it show strong anticancer activity. In this paper,the anticancer mechanism of EGCG in tea polyphenol and the research progress of EGCG nanocarrier technology were reviewed,which provided a reference for the application of tea polyphenol in cancer prevention and treatment. |
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| Keywords: | tea polyphenol EGCG anticancer nanocarrier technology |
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