大豆异黄酮与肠道微生物相互作用研究进展

膳食摄入大豆异黄酮与人体健康有密切的关系。大豆异黄酮糖苷组分与肠道菌群相互作用可产生生物活性和生物可利用度显著提高的新型微生物转化物，促进大豆异黄酮生理活性充分发挥。同时，大豆异黄酮通过调控肠道菌群结构影响结肠中的微生物酶活性，改变结肠菌群代谢能力。本文将对大豆异黄酮与肠道微生物的相互作用进行综述，重点阐述肠道微生物对大豆异黄酮的生物转化作用、大豆异黄酮对肠道微生物及其酶活性的调控作用以及大豆异黄酮及其肠道转化产物对健康的作用。以期为膳食组分和肠道菌群相互作用促进人体健康研究领域提供理论参考。

Progress in the Research of the Interactions of Soy Isoflavones with Gut Microbiota

Dietary intake of soy isoflavones has been demonstrated to be closely related to human health. The interaction of soy isoflavone glycosides with gut microflora can result in microbial transformation for significantly increased biological activity and bioavailability facilitating soy isoflavones to fully exert their physiological activity. Besides, soy isoflavones affect the microbial enzyme activities and change the microbial metabolic capacity in the colon by regulating the intestinal flora structure. This article reviews the interactions between soy isoflavones and gut microbes, with focus on the biotransformation of soy isoflavones by gut microbes and the regulation of gut microflora and its enzyme activities by soy isoflavones. The health effects of soy isoflavones and their intestinal metabolites are also addressed. This review aims to provide a theoretical basis for the study on the interactions between dietary components and intestinal flora in the field of human health promotion.