基于明胶硬胶囊性能评价的明胶—普鲁兰复合膜研究

制备了明胶-普鲁兰复合膜,通过测定复合膜的性质来指导评价硬胶囊的性能、优化硬胶囊囊材配比及降低其脆碎性和水蒸气透过系数(WVP),并通过透光率、傅立叶红外光谱、扫描电镜来表征明胶与普鲁兰的相容性。结果表明:甘油添加量为10%(干基百分比),明胶/普鲁兰质量比为9:1时,可用于明胶硬胶囊的共混改性。相比明胶膜,上述条件下制备的复合膜的WVP降低了26%,低湿环境下的断裂延伸率提高了1.19倍,复合膜中明胶与普鲁兰分子间具有良好的相容性,因此机械性能稳定性增强,WVP降低。

Study on the gelatin-pullulan composite films for performance evaluation of gelatin hard capsules

The gelatin-pullulan composite films were prepared.Then the properties of composite films were determined to provide a direction to evaluate the performance of hard capsules,optimize the ratio between capsule materials,and reduce the brittleness and water vapor permeability(WVP).The compatibility between gelatin and pullulan was characterized by light transmittance,Fourier transform infrared spectroscopy and scanning electron microscopy.The results indicated that it could be used for the blending modification of gelatin hard capsules when the glycerol addition was 10%(dry basis percentage),and the mass ratio between gelatin and pullulan was 9:1.The WVPof the composite films,prepared by the above conditions,was reduced by 26%compared with that of the gelatin films.The elongation at break was 1.19 times higher than the level of gelatin films in low humidity environment.There was good compatibility between the molecules of gelatin and pullulan in the composite films,whichcould explain the improvement of mechanical stability,and the reduction of WVP.