骨免疫机制及增强骨密度功能食品的新思考

以骨密度下降为代表的骨质疏松症是一种骨代谢疾病,同时也是一种炎症性疾病,已严重影响人们的生活质量。骨质疏松症的防治应引起高度的重视,药物治疗昂贵且有副作用。然而合理地摄入增强骨密度功能食品可以预防和延缓骨质疏松的发生和发展,促进人体健康。目前在增强骨密度功能食品中的功能成分多为钙、维生素D和硫酸软骨素等,而含有普通食物中功能成分的功能食品较少,因此增强骨密度功能食品的研究与开发有待深入挖掘。迄今为止, RANKL/RANK/OPG既可调控骨代谢也影响免疫系统,是骨免疫学领域较为重要的信号通路。本文概述了骨重建的生物学过程及增强骨密度功能食品的研究现状,并从骨免疫学的角度阐述了预防骨质疏松的新方法,以期为抗骨质疏松功能食品的开发提供新的靶点和思路。

Mechanism of osteoimmunology and the new perspective of functional foods beneficial for bone mineral density

Osteoporosis, represented by decreased bone density, is a kind of bone metabolism disease and inflammatory disease, which has seriously affected people''s quality of life. The prevention and treatment of osteoporosis should be paid enough attention, but the drug therapy is expensive and may cause side effects. However, moderate intake of functional foods of increasing bone density can prevent the occurrence and development of osteoporosis and promote health. At present, the calcium, vitamin D and chondroitin sulfate are the main active ingredients in the increasing bone density functional food and few functional ingredients came from common foods. Therefore, the research and development of increasing bone density functional foods needed to be explored. The RANKL/RANK/OPG signal system, an important signal pathway in the field of osteoimmunology so far, not only regulates bone metabolism but also affects the immune system. The article summarized the biological process of bone remodeling and development of functional foods for increasing bone density, and introduced new approach to prevent osteoporosis from the perspective of osteoimmunology, so as to provide new targets and ideas for the development of functional foods for anti-osteoporosis.