食源性天然产物中多糖干预炎症性肠病的研究进展

多糖类物质是具有生物活性的大分子物质，广泛存在于多种食源性物质中。炎症性肠病对结肠有广泛的损伤作用，并可能破坏免疫系统的动态平衡。尽管药物能够在一定程度上缓解炎症性肠病，但许多临床实践中的药物都有不良反应。研究表明，多糖类物质能有效预防和改善炎症性肠病引起的结肠损伤和免疫系统紊乱。本文主要对食源性天然产物中多糖类物质干预炎症性肠病的研究进展和发挥保护作用的相关分子机制进行综述，以期为预防炎症性肠病和营养干预机制的进一步研究提供参考。

Recent Progress in Food-Derived Natural Polysaccharide Intervention in Inflammatory Bowel Disease

Polysaccharides are biologically active macromolecules present in many plants. Inflammatory bowel disease causes extensive damage to the colon and disrupts immune system homeostasis. Although drugs can alleviate inflammatory bowel disease to some extent, many of them can cause adverse reactions in clinical practice. Polysaccharides have been shown to prevent or mitigate colon damage and immune system disorders caused by inflammatory bowel disease. In this article, recent advances in understanding the protective effects and molecular mechanisms of food-derived natural polysaccharides against inflammatory bowel disease are reviewed, which will hopefully provide a theoretical rationale for the prevention of inflammatory bowel disease and the mechanistic exploration of nutrition intervention strategies.