Cinnamomum camphora Seed Kernel Oil Ameliorates Oxidative Stress and Inflammation in Diet‐Induced Obese Rats |
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| Authors: | Jing Fu Cheng Zeng Zheling Zeng Baogui Wang Deming Gong |
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| Affiliation: | 1. State Key Laboratory of Food Science and Technology, Nanchang Univ, Nanchang, China;2. the First Clinical School, Nanchang Univ, Nanchang, China;3. the School of Environmental and Chemical Engineering, Nanchang Univ, Nanchang, China;4. School of Biological Sciences, The Univ. of Auckland, Private Bag, Auckland, New Zealand |
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| Abstract: | Cinnamomum camphora seed kernel oil (CCSKO) was found to reduce body fat deposition and improve blood lipid in both healthy and obese rats. The study was aimed to investigate the antioxidative stress and anti‐inflammatory effects of CCSKO in high‐fat‐diet‐induced obese rats. The obese rats were treated with CCSKO, lard, and soybean oil, respectively, for 12 wk. The level of total antioxidant capacity (T‐AOC), activities of superoxide dismutase (SOD), glutathione peroxidase, and catalase, and levels of malondialdehyde (MDA), tumor necrosis factor (TNF)‐α, peroxisome proliferator‐activated receptor (PPAR)‐γ, interleukin (IL)‐6, and P65 were compared among CCSKO, lard, and soybean oil groups. Our results showed that the level of T‐AOC and activities of SOD and catalase were significantly increased and the level of MDA was significantly decreased in CCSKO group. In addition, CCSKO treatment reduced the activities of serum glutamic oxaloacetic transaminase and glutamate‐pyruvate transaminase, and levels of serum TNF‐α, IL‐6, and P65 through raising the level of PPAR‐γ. In conclusion, CCSKO has, for the first time, been found to ameliorate oxidative stress and inflammation in high‐fat‐diet‐induced obese rats. |
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| Keywords: | Cinnamomum camphora seed kernel oil inflammation oxidative stress |
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