Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor |
| |
Authors: | Yuki Sugiura Melvin L. Munar Kunio Ishikawa |
| |
Affiliation: | 1.Department of Biomaterials, Faculty of Dental Science,Kyushu University,Higashi,Japan;2.Health Research Institute,National Institute of Advanced Industrial Science and Technology (AIST),Takamatsu,Japan |
| |
Abstract: | Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0?±?0.2?MPa. The macroporosity and microporosity of the OCP block were 33.4?±?4.5% and, 69.0?±?1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|