1.Ludwig Boltzmann Institute for Experimental and Clinical Traumatology,Vienna,Austria;2.Baxter Medical Products GmbH,Vienna,Austria
Abstract:
Two self-adhering hemostatic patches, based on either PEG-coated collagen (PCC) or PEG-coated oxidized cellulose (PCOC), are compared regarding to maximum burst pressure, mechanical stability, and swelling. In addition, the induction of tissue adhesions by the materials was assessed in a rabbit liver abrasion model. Both materials showed comparable sealing efficacy in a burst pressure test (37?±?16 vs. 35?±?8?mmHg, P?=?0.730). After incubation in human plasma, PCC retained its mechanical properties over the test period of 8?h, while PCOC showed faster degradation after the 2?h time-point. The degradation led to a significantly decreased force at break (minimum force at break 0.55?N during 8?h for PCC, 0.27?N for PCOC; p?p?=?0.003 and p?
