Ion release from magnesium materials in physiological solutions under different oxygen tensions |
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Authors: | Frank Feyerabend Heiko Drücker Daniel Laipple Carla Vogt Michael Stekker Norbert Hort Regine Willumeit |
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Affiliation: | (1) Institute for Material Research, Department of Macromolecular Structure Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, 21502 Geesthacht, Germany;(2) Institute for Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, 21502 Geesthacht, Germany;(3) Institute for Inorganic Chemistry, Leibniz University of Hannover, Callinstr. 9, 30167 Hannover, Germany;(4) MeKo, Im Kirchenfelde 12-14, 31157 Sarstedt/Hannover, Germany |
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Abstract: | Although magnesium as degradable biomaterial already showed clinical proof of concepts, the design of new alloys requires
predictive in vitro methods, which are still lacking. Incubation under cell culture conditions to obtain “physiological” corrosion
may be a solution. The aim of this study was to analyse the influence of different solutions, addition of proteins and of
oxygen availability on the corrosion of different magnesium materials (pure Mg, WE43, and E11) with different surface finishing.
Oxygen content in solution, pH, osmolality and ion release were determined. Corrosion led to a reduction of oxygen in solution.
The influence of oxygen on pH was enhanced by proteins, while osmolality was not influenced. Magnesium ion release was solution-dependent
and enhanced in the initial phase by proteins with delayed release of alloying elements. The main corrosion product formed
was magnesium carbonate. Therefore, cell culture conditions are proposed as first step toward physiological corrosion. |
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