Solubility of cyproheptadine in supercritical carbon dioxide; experimental and modeling approaches |
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Affiliation: | 1. Islamic Azad University, Dashtestan Branch, Borazjan, Iran;2. Chemical and Petroleum Engineering Department, School of Engineering, Shiraz University, Iran;1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, Iran;2. Laboratory of Supercritical Fluids and Nanotechnology, University of Kashan, 87317-53153 Kashan, Iran;3. Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, Iran;4. Research Centre for Computing, National Research and Innovation Agency (BRIN), Jl. Raya Jakarta-Bogor KM 46 Cibinong, Indonesia;1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, Iran;2. Laboratory of Supercritical Fluids and Nanotechnology, University of Kashan, 87317-53153 Kashan, Iran;3. Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, Iran;4. National Research and Innovation Agency (BRIN), Indonesia;5. School of Medicine, Shahid Beheshti University of Medical Sciences, 19839-69411 Tehran, Iran |
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Abstract: | Solubility of solute in supercritical fluids at different pressures and temperatures is one of the most important parameters necessary for design of any supercritical fluid-based processes. Among different supercritical fluids, carbon dioxide is one of the most widely used solvents due to its useful and green characteristics. In this work, with the assist of supercritical carbon dioxide as the solvent, solubility of cyproheptadine in different temperatures (308–338 K) and pressures (160–400 bar) are measured using static method. The obtained results demonstrated that solubility of cyproheptadine ranged between 3.35 × 10−5 and 3.09 × 10−3 based on mole fraction. A closer examination of measured solubility data show that not only solubility of cyproheptadine increases by increasing pressure but also experiences a cross over pressure about 200 bar. At last, the measured solubility data are correlated using four widely used density based correlations namely Mendez Santiago–Teja (MST), Kumar and Johnston (KJ), Bartle et al., and Chrastil models. The obtained results demonstrated that the best correlative capability was observed for KJ model leads to the average absolute relative deviation percent (AARD %) of 6.3%. |
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Keywords: | Cyproheptadine Solubility Supercritical carbon dioxide Correlation |
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