Synthesis of in situ functionalized iron oxide nanoparticles presenting alkyne groups via a continuous process using near-critical and supercritical water |
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| Affiliation: | 1. Fraunhofer Institute for Chemical Technology, Joseph-von-Fraunhofer-Str. 7, 76327 Pfinztal, Germany;2. Institute for Applied Materials (IAM) and Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany;3. Institute for Nanotechnology (INT) and Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany;4. Fraunhofer Institute for Molecular Biology and Applied Ecology, Forckenbeckstr. 6, 52074 Aachen, Germany;5. Soft Matter Synthesis Lab, Institute for Biological Interfaces, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany;6. Institute for Technical Thermodynamics and Refrigeration, Karlsruhe Institute of Technology (KIT), Engler-Bunte-Ring 21, 76131 Karlsruhe, Germany;1. Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii prospect, Petergof, St. Petersburg, 198504, Russian Federation;2. Ioffe Institute, 26 Politekhnicheskaya Street, St. Petersburg, 194021, Russian Federation |
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| Abstract: | The preparation of iron oxide nanoparticle dispersions of varying properties (e.g. color, crystal structure, particle size distribution) in a continuous hydrothermal pilot plant operating under near-critical and supercritical conditions with the aim of producing in situ functionalized nanoparticles suitable for secondary functionalization via click chemistry is reported. The effect of varying the mixing setup, reaction temperature and the starting material (iron salt) in the presence of different carboxylic acids on the resulting nanoparticle dispersions was investigated. The stability of the clickable ligands in the harsh hydrothermal environment was also tested and the clickability of the functionalized particles was demonstrated by means of XPS and fluorescence measurements after model click reactions. |
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| Keywords: | Supercritical hydrothermal flow synthesis Iron oxide nanoparticles Hybrid nanoparticles |
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