Quantitative assessment of risk associated with dietary intake of mycotoxin ochratoxin A on the adult inhabitants in Shanghai city of P.R. China |
| |
| Affiliation: | 1. Laboratory of Quality & Safety Risk Assessment for Agro-products (Shanghai), Ministry of Agriculture, Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, 1000 Jinqi Road, Shanghai 201403, PR China;2. Institute of Shanghai Food and Drug Supervision, 615 Liuzhou Road, Shanghai 200233, PR China;3. Laboratory of Food Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium;1. U.S. Environmental Protection Agency, National Exposure Research Laboratory, 109 TW Alexander Dr, Research Triangle Park, NC 27709, USA;2. U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, 109 TW Alexander Dr, Research Triangle Park, NC 27709, USA;1. State Key Laboratory of Tea Biology and Utilization, School of Tea and Food Science Technology, Anhui Agricultural University, Heifei 230036, China;2. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China;3. Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, China;1. Ministry of Food, Agriculture and Livestock, General Directorate of Food and Control, Food Control Laboratory, Adana, Turkey;2. Hitit University, Faculty of Engineering, Department of Food Engineering, TR-19030 Corum, Turkey;1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macau;1. Team of Applied Microbiology and Biotechnologies, BioMare Laboratory, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco;2. Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain |
| |
| Abstract: | Mycotoxin ochratoxin A (OTA) is considered to be a possible risk factor for adverse effects in humans. In the present study, quantitative assessment of risk associated with dietary intake of OTA was performed based on consumption habits of the representative adult inhabitants in Shanghai city of P. R. China. Firstly, a total of 400 food samples randomly collected from different locations of Shanghai were analyzed by the previously established isotope dilution LC–MS/MS method. Then, 265 participants of 70 males and 195 females as representative inhabitants were invited to answer the designed questionnaire about the quantity and frequency of foods including four major varieties of grapes, cereals, beans and dried fruits as well as their derived products. Finally, all data were simulated by the point evaluation and model evaluation for the risk assessment of OTA contamination. Results from the point evaluation indicated that mean value of daily intake (DI) of OTA was 1.147 ng/kg body weight/day, which was lower than all the reference standards. However, DI value (8.566 ng/kg body weight/day) in the high percentile (97.5th) was obviously higher than the PTDI (5 ng/kg body weight/day) proposed by Scientific Committee on Food. Among the different groups of foods, OTA in cereals and derived products made the largest contribution to the potential healthy risk. The mean DI value and 97.5th percentile were 1.093 and 7.962 ng/kg body weight/day, respectively, indicating that more than 90% of the risk was due to the contamination of OTA in cereals and derived products. On the other hand, similar results were obtained by the Monte Carlo assessment model. Thus, from the currently available data and analyzed results on the adult inhabitants, regarding OTA contamination issues on food safety administration of Shanghai, there was no significant attention which should be paid on food consumption in Shanghai, besides cereals and derived products with very little possibility as the risk factors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
