Solubility of chlorpheniramine maleate in supercritical carbon dioxide |
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| Affiliation: | 1. Islamic Azad University, Dashtestan Branch, Borazjan, Iran;2. Chemical and Petroleum Engineering Department, School of Engineering, Shiraz University, Iran;1. Chair of Animal Nutrition, TUM School of Life Sciences, Technische Universität München, Germany;2. Research Center for Nutrition and Food Science (ZIEL), TUM School of Life Sciences, Technische Universität München, Germany;1. Laboratory of Applied Research on the Characteristic Resources in the North of Guizhou Province, School of Chemistry and Chemical Engineering, Zunyi Normal College, Zunyi, Guizhou 563002, China;2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China;3. Library of Zunyi Normal College, Zunyi, Guizhou 563002, China |
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| Abstract: | Solubility of chlorpheniramine maleate in supercritical carbon dioxide at different temperatures (308–338 K) and pressures (160–400 bar) is measured using static method coupled with gravimetric method. The measured solubility data demonstrated that the solubility of chlorpheniramine maleate was changed between 1.54 × 10−5 and 4.26 × 10−4 based on the mole fraction as the temperature and pressure are changed. The general trend of measured solubility data shows a direct effect of pressure and temperature on the solubility of chlorpheniramine maleate. Finally, the obtained solubilities correlated using four semi-empirical density-based correlations including Mendez Santiago–Teja (MST), Kumar and Johnston (KJ), Bartle et al., and Chrastil models. Although the results of modeling showed that the KJ model leads to the average absolute relative deviation percent (AARD %) of 8.1% which is the lowest AARD %, deviation of other utilized correlations are rather the same. |
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| Keywords: | Solubility Supercritical carbon dioxide Chlorpheniramine maleate Correlation |
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