Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide |
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Affiliation: | 1. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China;2. The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China;3. State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510006, China |
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Abstract: | This study was aimed to measure the solubility of carvedilol in the temperature and pressure ranges of 308338 K and 160 bar to 400 bar, respectively. In this direction, a homemade high pressure visual equilibrium cell was used to measure the solubility of carvedilol using a static method coupled with gravimetric technique. The results revealed that the carvedilol solubility was ranged between 1.12 ÿ 105 and 5.01 ÿ 103 based on the mole fraction (mole of carvedilol/mole of carvedilol + mole of CO2) in this study as the temperature and pressure was changed. Finally, the results were correlated using four density-based semi-empirical correlations including Chrastil, MendezSantiagoTeja (MST), Bartle et al., and Kumar and Johnston (K-J) models. Results revealed that although the K-J model leads to the lowest average absolute relative deviation percent (AARD %) of 6.27%, but it could not be considered as the most accurate correlation since all the used four correlations introduces AARD % of about 610% which may be in the same range as the experimental error. |
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Keywords: | Carvedilol Supercritical carbon dioxide Solubility Correlation |
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