甘薯抗性淀粉对高脂血症大鼠降脂利肝作用研究

目的：考察甘薯抗性淀粉(SPRS)在大鼠形成高脂血症过程中的降血脂及促进肝损伤修复的作用。方法：取健康成年SD大鼠，雌雄各半，40只随机分为4组：正常对照组(NG)、高脂模型组(HL)、甘薯抗性淀粉低剂量组(SPRSL)、甘薯抗性淀粉高剂量组(SPRSH)。正常对照组饲喂基础饲料，高脂模型组饲喂高脂饲料，甘薯抗性淀粉组在高脂饲料的基础上分别给予甘薯抗性淀粉10、20g/(kg·d)，45d后测定大鼠血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量及观察肝脏组织细胞形态变化。结果表明：甘薯抗性淀粉能显著降低TC、TG、LDL-C水平，提高HDL-C水平；甘薯抗性淀粉组肝细胞变性和坏死现象明显轻于高脂模型组。结论：甘薯抗性淀粉对高脂饲料致高脂血症大鼠的血脂水平有较好的调节作用，并明显改善大鼠的肝功能。

Hypolipidemic and Liver-Benefiting Effect of Sweet Potato Resistant Starch in Hyperlipidemic Rats

Objective: To examine whether sweet potato resistant starch(SPRS) lowers blood lipid levels and benefits the liver of hyperlipidemic rats.Methods: Forty SD rats(half male and half female) were randomly divided into 4 groups including normal control group,hyperlipidemia model group,SPRS low-dose group and SPRS high-dose group.Rats fed a normal diet were served as the normal control group and rats fed a high-fat diet as the hyperlipidemia model group.The rats in SPRS groups were administered with SPRS by gavage at the daily doses of respectively 10 g/(kg·d) and 20 g/(kg·d) and also fed a high-fat diet.After 45 days of administration,serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C) and morphological changes in the liver of all the rats were examined.Results: SPRS could significantly reduce the contents of TC,TG and LDL-C,and increase the content of HDL-C in rat serum.Meanwhile,the liver degeneration and damage of the SPRS groups were markedly attenuated compared with the hyperlipidemia model group.Conclusion: SPRS has an excellent regulatory effect on blood lipid level and enhances the recovery of liver damage in rats with hyperlipidemia.