| 5-乙酰基-2,3-二氢苯并呋喃的合成 |
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| 引用本文： | 郑静,方霞.5-乙酰基-2,3-二氢苯并呋喃的合成[J].精细化工中间体,2007,37(4):34-35,62. |
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| 作者姓名： | 郑静 方霞 |
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| 作者单位： | 湖北师范学院,化学与环境工程系,湖北,黄石,435002 |
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| 摘 要： | 采用邻溴苯酚为初始原料,在相转移催化剂作用下经烷基化合成2-(2-氯乙氧基)-1-溴苯(1),通过生成格氏试剂合成2,3-二氢苯并呋喃(2),由傅-克酰基化反应合成5-乙酰基-2,3-二氢苯并呋喃(3)。反应过程以薄层色谱法监控,并通过元素分析、1HNMR对各中间体的组成和结构进行了确证和表征。
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| 关 键 词： | 5-乙酰基-2 3-二氢苯并呋喃 薄层色谱 合成 |
| 文章编号： | 1009-9212（2007）04-0034-02 |
| 修稿时间： | 2007-05-28 |
Synthesis of 5-Acetyl-2,3-dihydrobenzofuran |
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| ZHENG Jing,FANG Xia.Synthesis of 5-Acetyl-2,3-dihydrobenzofuran[J].Fine Chemical Intermediates,2007,37(4):34-35,62. |
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| Authors: | ZHENG Jing FANG Xia |
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| Affiliation: | Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002, China |
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| Abstract: | Reaction of 2-bromophenol with 1,2-dichloroethane via alkylation in the presence of the phase transfer catalysis and sodium hydroxide afforded 1-bromo-2-(2-chloroethoxy)benzene(1),and then reacted with magnesium and 1,2-dibromoethane in anhydrous tetrahydrofuran to produce 2,3-dihydrobenzofuran(2) followed by Friedel-crafts acetylation with acetyl chloride by using aluminum chloride as catalysis in dichloromethane to give 5-acetyl-2,3-dihydrobenzofuran(3). The reaction process was monitored by TLC,and the compositions and structures of the intermediates were confirmed by means of elemental analysis and 1H NMR. |
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| Keywords: | 5-acetyl-2 3-dihydrobenzofuran TLC synthesis |
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