| 2,5-二甲氧基苯乙胺的合成 |
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| 引用本文： | 黄红霞,林原斌. 2,5-二甲氧基苯乙胺的合成[J]. 精细化工中间体, 2007, 37(3): 70-72 |
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| 作者姓名： | 黄红霞 林原斌 |
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| 作者单位： | 桂林工学院,材料与化学工程系,广西,桂林,541004;湘潭大学,化学学院,湖南,湘潭,411105 |
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| 摘 要： | 选取了一条合理、成本相对低廉的合成2,5-二甲氧基苯乙胺新方法。在碱性条件下,对苯二酚经醚化得到1,4-二甲氧基苯,收率95.0%,再选用高选择性的溴化剂溴化后,收率90.0%,经格氏反应和羟乙基化反应制备2,5-二甲氧基苯乙醇,收率75.0%,醇与对甲苯磺酰氯反应得到酯,收率97.0%,最后经Gabriel反应可以制备相应的芳香乙胺化合物,收率70.0%。该路线反应较易,条件温和,对设备要求较低,原料价廉易得,适合工业生产。
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| 关 键 词： | 2 5-二甲氧基苯乙胺 格氏反应 Gabriel反应 |
| 文章编号： | 1009-9212（2007）03-0070-03 |
| 修稿时间： | 2007-03-13 |
Synthesis of 2,5-Dimethoxy Phenethylamine |
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| HUANG Hong-xia,LIN Yuan-bin. Synthesis of 2,5-Dimethoxy Phenethylamine[J]. Fine Chemical Intermediates, 2007, 37(3): 70-72 |
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| Authors: | HUANG Hong-xia LIN Yuan-bin |
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| Affiliation: | 1. The Department of Material and Chemistry of Guilin Institute of Technology, Guilin 541004, China; 2 College of Chemistry, Xiangtan University, Xiangtan 411105, China |
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| Abstract: | A new route to produce 2,5-dimethoxy phenethylamine was introduced in the paper. Under the basic condition,1,4-dihydroxy benzene was reacted with dimethyl sulfate to get 1,4-dimethoxy benzene with 95.0% of the yield. 1,4-dimethoxy benzene was brominated with high-selective bromating agent to produce 1,4-dimethoxy benzene bromide with 90% of yield. 2,5-dimethoxy phenethanol was synthesized from 1,4-dimethoxy benzene bromide through Grignard reaction and hydroxyethylation(the yield 75.0%),and esterification(the yield 97.0%) and Gabriel reaction(the yield 70.0%). Though there are five steps in this route,but the conditions are mild and easy to carry out,so it is of extensive industrial perspective. |
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| Keywords: | 2 5-dimethoxy phenethylamine Grignard reaction Gabriel reaction |
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