Possible association between nickel and chromium and oral cancer: a case-control study in central Taiwan |
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| Authors: | Yuan Tzu-Hsuen Lian Ie-Bin Tsai Kuo-Yang Chang Tsun-Kuo Chiang Chi-Ting Su Che-Chun Hwang Yaw-Huei |
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| Affiliation: | a Graduate Institute of Occupational Medicine & Industrial Hygiene, National Taiwan University, Taipei City 100, Taiwanb Graduate Institute of Statistics & Information Science, National Changhua University of Education, Changhua 500, Taiwanc Department of Dentistry, Changhua Christian Hospital, Changhua 500, Taiwand Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei City 106, Taiwane Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwanf Department of Public Health, College of Public Health, National Taiwan University, Taipei City 100, Taiwan |
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| Abstract: | Oral cancer is one of the most common cancers in Taiwan. Changhua County, in central Taiwan, has an extremely high prevalence of oral cancer, along with a high concentration of metal-related industries and soil metal contamination. The aim of this study was to clarify the possible association between metals and oral cancer within this specific area. This study recruited 101 oral cancer patients and 104 controls from the Changhua Christian Hospital. All subjects completed a questionnaire that asked about demographic information; cigarette, alcohol, and betel quid use; and environmental and occupational exposure history. Blood samples were collected and tested for metal concentrations with inductively coupled plasma mass spectrometry. A multiple logistic regression model illustrated that oral cancer was significantly associated with the blood levels of nickel and chromium (both with P < 0.0001) after controlling for potential confounders. This study suggested a potential role of these two metals in the mechanism of oral cancer development. |
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| Keywords: | Oral cancer Nickel Chromium Betel quid Blood |
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